Man cannot come to terms with a short maturity of life. Scientists are looking for a key mechanism of aging is changing that can drastically increase its duration. They are trying to somehow influence the endocrine system, affecting the development of the organism, or telomeres with telomerase, which determine the shortening of chromosomes during cell division. Experiment with antioxidants, able to protect tissues against free radicals. Seek to slow the elimination of short-lived cells of the central nervous system or enhance the reproduction of stem cells. With all the differences, the aim of this research is to slow the natural aging process, which is not possible to achieve.
Consider a fundamentally different way of increasing life expectancy – not protecting the body from the natural, and from premature aging and associated chronic diseases. It will in the near future to postpone aging is genetically predetermined limits, which, according to experts, are 150 – 200 years.
Pros and cons of the high threshold of immunological tolerance
The immune system does not always protect the body from physical factors that serve potential sources of chronic diseases and premature aging syndrome: mutant cells, inert proteins and lipids, atrophic nerve fibers, etc. The reason is that it has a special subsystem immunological tolerance that blocks immune. Answers to latent pathogens that do not pose a threat now. This immune system is free from inefficient spray forces maintains resources to deal with the sources of acute pathogenesis. A side effect of such a rational function of the immune system – the body from chronic exposure processes that lead to premature aging. The components of the block are immunological tolerance of the immune system cells, including some T lymphocytes.
The choice of somatic antigens and pathogens to immune responses, which are sent, and those that remain without depends on immunological tolerance threshold. Different species it varies. The higher the threshold, the less protection against premature aging of sources. In humans, it is very high, because established as a result of natural selection, which took place in ancient times, when the main causes of death were: hunger, war, epidemics, natural disasters, and not old. Only in our time improving the socio-economic conditions and medical advances have dramatically increased life expectancy, and high immunological tolerance has become a “Domoklov sword” of humankind.
To the immune system to promptly deliver the body from premature aging of the sources, it is necessary to create an additional control mechanism of immunological tolerance. We call it the “Internal immunity controller» (The internal immunity controller) or IC. Its task: to vary the reproduction of certain immune cells, thereby lowering the threshold for the duration of immunological tolerance and to expand the range of immune responses. Expected result – the elimination of sources of neurodegenerative, oncological, cardiovascular disease.
To periods of over- and immunological tolerance does not affect the total resistance is required to monitor the reproductive resources of the immune system and build an individual passport dynamics of physiological states of the body. Peripheral units monitoring system will be sensors that detect various biometric indicators: body temperature, pulse, RAG, myogram, the blood and others. They can be integrated into a mobile phone or a special bracelet. Indications will be automatically transmitted to the information center serving all network IC users. Data processing in real time can help neurocomputing information technologies, which have already found application in medicine.
Immune control keys
There is reason to assume that the immunological tolerance of the control keys will be specially selected or artificially modified retroviruses like the human immunodeficiency virus (HIV). The properties of some of them have been investigated in a number of research centers. It is known that HIV infection leads to sharp fluctuations of immunological tolerance threshold caused recession reproduction immune system cells. At the same immune responses directed to somatic abnormalities that before HIV ignored:. Atrophied tissue and nerve fibers, scarring, polyps, ulcers, etc. The front of the activity of the immune system increases, its resources are reduced. Some infected immune depletion grows like a chain reaction, causing AIDS and its related disorders irreplaceable vital organs. The negative role played by drug addiction, co-morbidities, the wrong treatment. Other infected after each immunological tolerance threshold reduction period starts activation of reproductive resources, and its level is gradually recovering.
At the stage of the network IC, its first patients can be persons who are infected with HIV. By monitoring the functional state of the immune system, they have chosen the optimum mode of immunological tolerance threshold of vibrations that would eliminate errors in the treatment and prevention of opportunistic diseases lead. Immunodeficiency Virus will play the role of experimental key to adjust the immunity of the controller and the detailed design of the system of protection against AIDS and premature aging.
The question is whether it is possible to delay premature aging, without interfering with the immune system. It is known that the activation of the body’s defenses by the time of destabilization – element of many of the ancient and modern medical practices. Different techniques from primitive as starvation, bleeding, poisoning easy to complex hardware techniques, reflexology, various rejuvenating tablets, cloned stem cells, and hormones. Often, they allow you to temporarily increase the resistance, improve health, but cannot withstand aging. The fact that all the influences exerted on the body from the outside, he adapts quickly and they lose strength. For anti-aging need to regulators of immune tolerance of the immune system, owned and always maintained efficiency.
The action plan and research program:
- Collect and organize scientific material for immunological tolerance.
- To collect statistics on the types and terms of premature aging syndrome.
- Create a reliable classification of immunodeficiencies and related diseases. (It is unreliable). There a lot of biased information, dictated by pharmacists. It is especially associated with HIV and AIDS. Mortality is indicated differently. There is evidence that HIV-infected meets only a few types of cancer, the others are not observed.
- Build the available sensor units for monitoring physiological states of the body, more complete than those that apply to cardiology. Find correlation dynamics parameters of the immune system, both acute and chronic morbidity.
- Identify the factors that may be the key to the management of immunological tolerance. Primarily those under reduce its self-healing.
The encouraging results
Researchers at the US Mayo Clinic found that the destruction of the aged cells accumulate in the body with age, helping to delay the illness and functional limitations caused by aging. The experiment was conducted on mice, is the first evidence that cells grown old are related to age-related diseases. By destroying these cells and their metabolic products, doctors can destroy the relationship between aging and a number of co-morbidities. Over time, methods of treatment and prevention will be radically changed. It will prevent heart disease, heart attacks, various types of cancer and dementia. So says the head of the Clinical Center on Aging Dr. James Kirkland.
Half a century ago, scientists discovered that cells are able to share a limited number of times. Then comes the phase of cellular senescence, when their metabolic products damage adjacent cells and tissues. The immune system is partially relieves the body from such cells, but eventually begins to perform this function worse that. As a result, grown old cells accumulate. The question of whether or not they are related to age-related diseases has been open for many years.
During the experiment, it was found out that the destruction of the aged cells leads to an improvement in a number of physiological aspects of mice. Thus, the researchers were able to prevent cataracts, weakness and loss of muscle mass. Moreover, it appears that because of the procedures, which have undergone a mouse with advanced disease, their health improved. The results are published in Nature.